Published Articles (Physiology)

Efficacy of Sulbutiamine-a Fat Soluble Thiamine in the Management of Diabetic Symmetrical Peripheral Neuropathy

2025-07-04T03:11:12Z

Efficacy of Sulbutiamine-a Fat Soluble Thiamine in the Management of Diabetic Symmetrical Peripheral Neuropathy Amna Rizvi, Mehwish Iftikhar; Suresh Kumar, Ghazala Jawaad; Asmaa Khalid Objective: To evaluate the efficacy of sulbutiamine, a fat-soluble derivative of vitamin B1, in reducing pain intensity among diabetic patients with painful symmetrical peripheral neuropathy (DSPN). Material And Methods: Our quasi-experimental study involved 320 diabetic patients with painful symmetrical peripheral neuropathy, selected through non-probability purposive sampling from the Institute of Endocrinology and Metabolism, Services Hospital Lahore, between March 1, 2023, and August 31, 2023. Participants were administered Sulbutiamine, a fat-soluble derivative of vitamin B1-thiamine, at a dosage of 200mg twice daily over six weeks. Follow-up assessments were conducted at 3 and 6 weeks, with efficacy evaluated based on a minimum two-point improvement in pain intensity using the Numeric Pain Rating Scale. Results: 2 Demographic analysis revealed an average patient age of 59.49 years, a BMI of 30.10 kg/m, and a slight male predominance (55.9%). The final efficacy of fat-soluble thiamine at the 6th week was 68.4%. Stratified analysis highlighted significant variations in efficacy at 3rd and 6th weeks, emphasizing the influence of variables such as age, comorbidities, and diabetes duration. Age, comorbidities, and diabetes duration exhi bited strong statistical significance (p < 0.05), indicating their impact on treatment outcomes, while other variables demonstrated variable significance at different assessment points. Conclusion: In conclusion, the administration of sulbutiamine, a fat-soluble form of vitamin B1, led to a note worthy reduction in pain among diabetic individuals suffering from painful symmetrical peripheral neuropathy. This study underscores the potential of sulbutiamine as an effective intervention for managing DSPN, with implications for improving the well-being of diabetic patients. Associate Professor, Dr. Ghazala Jawwad Department of Physiology BUCM

Impact of Different Breakfast Habits Healthy, Unhealthy and Breakfast Skipping on Heart Rate Variability Amongst Adults

2026-01-07T06:49:48Z

Impact of Different Breakfast Habits Healthy, Unhealthy and Breakfast Skipping on Heart Rate Variability Amongst Adults Syeda Nayab Qamar, Humaira Fayyaz Khan; Shazia Ali, Saba Shoukat; Madeeha Maqsood, Ghazala Jawwad Objective: To determine the effect of breakfast taking habits on Heart Rate Variability (HRV) amongst adults. Methodology: This cross-sectional study was conducted in department of Physiology, IIMC from September 2022 to August 2023. It included 216 healthy, unhealthy breakfast consumers and breakfast skippers. We used Breakfast Quality Evaluation questionnaire. The ECG of the participants was recorded using power lab data acquisition system. Heart rate variability (HRV) was analyzed for frequency domain parameters including Low Frequency (LFnu), High Frequency (HFnu) and Low Frequency to High Frequency (LF/HF) ratio by software lab chart 8 pro on two consecutive days and average value was considered. One way ANOVA in SPSS version 25 was used to analyze data. Results: LFnu was significantly low in healthy than unhealthy breakfast consumers (p=0.028) and skippers (p<0.001). Significantly low LFnu found in unhealthy breakfast consumers than skippers (p=0.033). A significantly high HFnu found in healthy breakfast consumers than skippers (0.022). LF/HF ratio was significantly low in healthy than unhealthy breakfast consumers (p=0.002) and skippers (p<0.001). Results were considered significant at 95% CI. Conclusion: The breakfast taking habits of healthy, unhealthy and breakfast skipping had impact on HRV. Healthy breakfast was associated with increased HRV as compared to unhealthy and breakfast skipping. Associate Professor Dr. Ghazala Jawwad, BUCM, Department of Physiology

Higher Frequency of Thyroid Dysfunction in Type 2 Diabetes Mellitus is Independent of Deranged Lipid Profile in Streptozotocin Induced Diabetic Sprague Dawley Rats

2025-07-04T03:09:08Z

Higher Frequency of Thyroid Dysfunction in Type 2 Diabetes Mellitus is Independent of Deranged Lipid Profile in Streptozotocin Induced Diabetic Sprague Dawley Rats Sidra Arshad, Mahvash Khan; Hira Ayaz, Anjum Syed; Ghazala Jawwad, Nasar Abbas Shamsi Objective: To explore the role of dyslipidemia in development of thyroid disorder in type two diabetes mellitus. Methodology: In this randomized control trial, 60 Sprague Dawley rats were divided into two groups with 30 rats in each group. Group 1 (control group) was fed on normal pellet diet and water whereas group two (diabetic group) was fed high fat diet to produce insulin resistance. After 2 weeks, an intra-peritoneal injection of normal saline was given to all the rats in group 1, and group 2 rats were given single intra peritoneal injection of Streptozocin (35 mg/kg) to produce hyperglycemia. At the end of study period (8 weeks), serum lipid profile, triiodothyronine, thyroxine and thyroid stimulating hormone levels were measured. Pearson correlation coefficient was calculated to find correlation between lipid profile and thyroid profile. Results: There was no significant correlation of thyroid stimulating hormone, triiodothyronine and thyroxine with the parameters of lipid profile. Conclusion: The deranged lipid profile had no role in disturbing the thyroid hormone levels in STZ induced type 2 diabetic Sprague Dawley rats. Associate Professor, Dr. Ghazala Jawwad Department of Physiology BUCM

Exercise Induces Autonomic and Neuro-endocrine Response among Psychologically Stressed Medical Students

2025-07-04T03:08:33Z

Exercise Induces Autonomic and Neuro-endocrine Response among Psychologically Stressed Medical Students Ghazala Jawwad, Humaira Fayyaz Khan; Mehwish Iftikhar, Azhar Hussain; Sidra Arshad, Lubna Siddique Background: Psychological stress activates Hypothalamic- Pituitary- Adrenal axis (HPA) and Sympathoadrenal (SMA) axis”. Exercise has stress buffering action and it improves HRV and normalizes the cortisol response to stress. Aim: To evaluate the effect of moderate exercise in stabilizing autonomic and neuro-endocrine response to Psychological stress”. Study design: Randomized experimental study. Methodology: 100 MBBS students were engaged through DASS (Depression anxiety stress scale) proforma. They were divided into two groups; stress and control. HRV and serum cortisol levels were obtained. Stressed group did regular moderate exercise for 06 weeks. Independent t test was employed to see the difference in two parameters among the two groups. A p value of ≤ 0.05 was taken as significant. Results: After the intervention stressed group exhibited prominent decrease in LF/HF, LFnu, LFms2” and serum cortisol (0.009,0.033,.027 and 0.007 respectively. HFnu was significantly improved post exercise (.004). Significant reduction in serum cortisol was observed in stressed group after exercise (.007). Conclusion: Exercise can be employed to buffer the effect of psychological stress as it normalizes HPA axis” and autonomic response. Associate Professor, Dr. Ghazala Jawwad Department of Physiology BUCM